Professor Teresa Thurston
Subject: Medicine and Biomedical Science, Molecular and Cellular Biochemistry
Academic position: Official Fellowship as Tutor in Cell and Molecular Biology, in association with an Associate Professorship of Cell and Molecular Biology
Contact
Background
Teresa studied Natural Sciences as an undergraduate at the University of Cambridge and later obtained her Ph.D. in innate immune signalling under the supervision of Dr. Felix Randow at the Laboratory of Molecular Biology, University of Cambridge. Following her Ph.D., Teresa carried out a postdoctoral position with Prof. David Holden, at Imperial College London, and was funded by a Leverhulme Trust Research Fellowship and then an Imperial College Research Fellowship. In 2018 she was awarded a BBSRC David Philips Fellowship to establish her research group, studying Salmonella pathogenesis and innate immune signaling. She joined the University of Oxford in 2024 as Associate Professor of Cellular and Molecular Biology and runs a research group at the Sir William Dunn School of Pathology.
Undergraduate Teaching
At Magdalen, I teach Cellular and Molecular biology to medical and biomedical science students.
Research Interests
Using an array of multidisciplinary techniques our aim is to carry out fundamental discovery science on the mechanisms of bacterial infections. To this end, we study how Salmonella and Burkholderia, two intracellular Gram-negative human pathogens, manipulate host cell signalling to create their replicative niche.
Selected Recent Publications
Modulation of Salmonella virulence by a novel SPI-2 injectisome effector that interacts with the dystrophin-associated protein complex. Yu X-J, Xie H, Li Y, Liu M, Hou R, Predeus AV, Perez Sepulveda BM, Hinton JCD, Holden DW, Thurston TLM. mBio. 2024 Jul 17;15(7):e0112824. doi: 10.1128/mbio.01128-24. Epub 2024 Jun 21.PMID: 38904384
Bacterial esterases reverse lipopolysaccharide ubiquitylation to block host immunity. Szczesna M, Huang Y, Lacoursiere RE, Bonini F, Pol V, Koc F, Ward B, Geurink PP, Pruneda JN, Thurston TLM.Cell Host Microbe. 2024 Jun 12;32(6):913-924.e7. doi: 10.1016/j.chom.2024.04.012.PMID: 38870903
Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization. Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM.Cell Host Microbe. 2020 Jan 8;27(1):41-53.e6. doi: 10.1016/j.chom.2019.11.002. Epub 2019 Dec 17.PMID: 31862381
Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB. Jennings E, Esposito D, Rittinger K, Thurston TLM. J Biol Chem. 2018 Sep 28;293(39):15316-15329. doi: 10.1074/jbc.RA118.004255. Epub 2018 Jul 26.PMID: 30049795
SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-κB Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages. Günster RA, Matthews SA, Holden DW, Thurston TLM. Infect Immun. 2017 Feb 23;85(3):e00010-17. doi: 10.1128/IAI.00010-17. Print 2017 Mar.PMID: 28069818
Department Staff
Dr Sebastian Fica
Professor Richard Cornall
Professor Hugh Dickinson
Professor Timothy Barraclough
Professor John Stein
Dr Zhe (Luke) Ji
Professor Quentin Sattentau
Professor Laura Fortunato
Professor Stephen Goodwin
Professor Andrew Smith
Professor Maheshi Ramasamy
Professor Sir Adrian Hill KBE
Professor Sir Peter Ratcliffe
Dr Rebecca Shakir
Professor Lars Østergaard
Professor Eunyoung Chae
Dr Lauren Phillips
The Revd Professor Robert Gilbert
Professor Peter Sullivan
Dr Lydia France
Professor Gero Miesenböck
Professor Michael Goldacre
Professor Chris Garland
