Professor Sir Adrian Hill KBE

Subject: Medicine and Biomedical Science

Department: Medicine

Contact

Background

Adrian Hill moved from Trinity College, Dublin to Magdalen as an undergraduate in 1978. He read medicine and then undertook a DPhil focused on the genetics of Pacific Islanders. He joined the Weatherall Institute of Molecular Medicine as a Wellcome Trust Senior Fellow in 1988 and began work on immunogenetics in West Africa that led to his current interest in malaria vaccine design and development. He is now the Director of the Jenner Institute (www.jenner.ac.uk), which he founded in 2005, and the Lakshmi Mittal & Family Professor of Vaccinology. The Jenner Institute, focuses on designing and developing vaccines for infectious diseases prevalent in developing countries, such as HIV/AIDS, malaria and tuberculosis.

Teaching

He is the academic lead for a Master’s level course on Human and Veterinary Vaccinology, and co-directs a module on vaccinology for the MSc in International Health and Tropical Medicine. He has supervised over 50 DPhil students.

Research Interests

Adrian trained in medicine at Trinity College, Dublin and then Magdalen (BA 1979) and later undertook a DPhil in human genetics before clinical specialist accreditation in infectious diseases. In 1994 he was one of the founding scientists of the Wellcome Trust Centre for Human Genetics, where he directs a research programme on genetic susceptibility factors impacting bacterial diseases and vaccine responses. Since the late 1990s he has developed a leading malaria vaccine programme, spanning over 60 clinical trials in Europe and Africa, with one vaccine now showing high level efficacy and in late stage development. This programme has introduced and validated particularly immunogenic vaccine technologies including chimpanzee adenoviral vectors and virus-like particles in saponin adjuvants.

In 2005 he founded the Jenner Institute at Oxford University to accelerate academic vaccine development for a range of infectious diseases, and partnered with the Pirbright Institute on veterinary vaccine development. The Jenner Institute is now the largest academic vaccine centre globally with clinical-stage vaccine programmes against sixteen diseases, including HIV, TB, emerging pathogens and cancer. In 2020, with many others at the Institute, he helped develop and partner a new chimpanzee adenoviral vector-based COVID-19 vaccine to achieve licensure and large-scale manufacture in less than a year. By 2021, this was the most widely distributed vaccine against COVID-19 and saved an estimated 6.2 million lives in that year. He is a passionate believer in the power of molecular medicine to design and deliver new health care interventions that will improve the lives of the poorest billion in sub-Saharan Africa and elsewhere. This contribution was recognised by the award of a KBE in the 2021 Queen’s Birthday Honours list.

His main current vaccine research programme has developed a low cost high efficacy vaccine for malaria, called R21/Matrix-M, in partnership with the Serum Institute of India. This vaccine, now being rolled out in Africa after regulatory approvals, is the highest efficacy vaccine yet tested at scale and promises to have a major impact in reducing malaria deaths in African children.
He has published over 600 research papers with >90,000 citations and has co-founded several spin-off companies. He is a Fellow of the UK Academy of Medical Sciences, the Royal College of Physicians and the Royal Society. Since 2004 he has been a Supernumerary Fellow and then Fellow by Special Election at Magdalen and is now the Lakshmi Mittal and Family Professor of Vaccinology at the Jenner Institute in the Nuffield Department of Medicine.

Selected Publications

Department Staff

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Professor Gero Miesenböck

Department: Physiology, Anatomy and Genetics

Appointment: Professorial Fellow

Email: gero.miesenboeck@cncb.ox.ac.uk

Tel: 01865 282261

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Dr Rebecca Shakir

Department: Medicine

Academic position: Sherrington Lecturer

Email: rebecca.shakir@ndph.ox.ac.uk

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Dr Maheshi Ramasamy

Department: Paediatrics

Appointment: Florey Lecturer and Fellow by Special Election

Academic position: Associate Professor

Email: maheshi.ramasamy@magd.ox.ac.uk

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Professor Quentin Sattentau

Department: Pathology

Appointment: Emeritus Fellow

Email: quentin.sattentau@magd.ox.ac.uk

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The Revd Professor Robert Gilbert

Department: Biochemistry and Medicine

Appointment: Tutorial Fellow, Vice President

Email: robert.gilbert@magd.ox.ac.uk

Tel: 01865 276070

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Professor Peter Sullivan

Department: Paediatrics

Email: peter.sullivan@paediatrics.ox.ac.uk

Tel: 07825 335477

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Chris Garland

Professor Chris Garland

Department: Pharmacology

Appointment: Tutorial Fellow

Officer: Senior Dean of Arts

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Professor John Stein

Appointment: Emeritus Fellow

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Professor Richard Cornall

Department: Medicine

Appointment: Professorial Fellow

Academic position: Nuffield Professor of Medicine, Head of Department

Email: richard.cornall@ndm.ox.ac.uk

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Dr Lauren Phillips

Department: Medicine and Biomedical Sciences

Academic position: Fellow by Examination

Email: lauren.phillips@pharm.ox.ac.uk

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Sir Peter Ratcliffe Oxford

Professor Sir Peter Ratcliffe

Department: Nuffield Department of Medicine

Appointment: Fellow by Special Election

Email: peter.ratcliffe@ndm.ox.ac.uk

Tel: 01865 612680

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Dr Dominic Alonzi

Department: Biochemistry

Email: dominic.alonzi@bioch.ox.ac.uk

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Professor Michael Goldacre

Department: Population Health

Email: michael.goldacre@dph.ox.ac.uk

Tel: 01865 289377

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Professor Stephen Goodwin

Department: Physiology, Anatomy and Genetics

Appointment: Tutorial Fellow

Email: stephen.goodwin@cncb.ox.ac.uk

Tel: 01865 272454