
Professor Chris Garland
Subject: Biology, Plant Sciences and Zoology, Medicine and Biomedical Science
Department: Pharmacology
College appointment: Tutorial Fellow
Contact
Background
I am a Tutorial Fellow in Medicine and Biomedical Science and in the university Professor of Vascular Pharmacology, where I run a research group in the Department of Pharmacology on Mansfield Road. Since 2013 I have also been a Visiting Professor at the University of Queensland, Australia. Previously, I was Head of Pharmacology (established chair) at the University of Bath and before that Reader then Professor of Cardiovascular Pharmacology, University of Bristol. I have held visiting Professorships at the University of Bath (2008-12), University of Nagoya, Japan (2011), Monash University, Australia (2000-2003) and the National Academy of Sciences, Taiwan (2003) and served as Vice-President of the British Pharmacological Society, on the council of the Royal Society of Biology, and as a member of grant panels for the Wellcome Trust, British Heart Foundation and the Medical Research Council. In 2009, I was awarded the British Pharmacological Society JR Vane Medal, recognizing outstanding research achievements in vascular pharmacology.
Undergraduate Teaching
At Magdalen, I teach Physiology and Pharmacology to medical and biomedical science students.
Research Interests
My research investigates the cellular signalling mechanisms controlling the smallest arteries in the body, hair-like structures that determine the pressure and flow of blood. The research aims to understand how these minute vessels are affected by disease that leads to stroke and myocardial ischaemia/infarction (heart attack).
Selected Recent Publications
- Boguslavskyi et al. (2021) Phospholemman phosphorylation regulates vascular tone, blood pressure and hypertension in mice and humans Circulation 16,1123-1138.
- Smith JF, Lemmey HAL, Borysova L, Hiley CR, Dora KA, Garland CJ. (2020) Endothelial nitric oxide suppresses action-potential-like transient spikes and vasospasm in small resistance arteries. Hypertension 76, 785-794.
- Lemmey HAL, Garland CJ, Dora KA. (2020) Intrinsic regulation of microvascular tone by myoendothelial feedback circuits. Curr Top Membr. 85, 327-355.
- Ye X, Beckett T, Bagher P, Garland CJ, Dora KA. (2018) VEGF-A inhibits agonist-mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells. J Physiol. 596, 3553-3566.
- Pinkney AMH, Lemmey HAL, Dora KA, Garland CJ. (2017) Vasorelaxation to the nitroxyl donor isopropylamine NONOate in resistance arteries does not require calcitonin gene-related peptide. Hypertension 70, 587-593.
- Garland CJ, Dora KA. (2017) EDH: endothelium-dependent hyperpolarization and microvascular signalling. Acta Physiol (Oxf). 219, 152-161.
- Garland CJ, Bagher P, Powell C, Ye X, Lemmey HAL, Borysova L, Dora KA. (2017) Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles. Science Signaling. 10 (486). pii: eaal3806. doi:10.1126/scisignal.aal3806.
Department Staff

Dr Dominic Alonzi

Professor Michael Goldacre

Professor Stephen Goodwin

Dr Sebastian Fica

Professor Sir Peter Ratcliffe

Professor Adrian Hill, Kt.

Professor Peter Sullivan

Professor Quentin Sattentau

Professor Gero Miesenböck

Dr Maheshi Ramasamy

Professor Richard Cornall

The Revd Professor Robert Gilbert

Professor Andrew Smith

Professor John Stein

Dr Lauren Phillips

Dr Rebecca Shakir

Dr Rachel Wheatley
