Dr Sebastian Fica

Subject: Molecular and Cellular Biochemistry

Department: Biochemistry

College appointment: Senior Demy


Sebastian Fica was born in Romania and studied in the United States, where he received his BA in molecular biology from Skidmore College in 2007 and his PhD in cell and molecular biology from The University of Chicago in 2013. From 2014 to 2021 he pursued postdoctoral work in the laboratory of Kiyoshi Nagai at the MRC Laboratory of Molecular Biology in Cambridge, being supported by an EMBO Long Term Fellowship and a Marie Sklodowska Curie Fellowship. In 2021 he was appointed a Wellcome Trust and Royal Society Sir Henry Dale Fellow to start his independent research group in The Department of Biochemistry at Oxford University. He joined Magdalen College as a Senior Demy in 2021.


Sebastian’s research focuses on the molecular mechanisms of pre-mRNA splicing. During gene expression, DNA is transcribed into pre-messenger RNAs (pre-mRNAs), which are spliced through the excision of non-coding introns to produce mature RNAs (mRNAs) with continuous protein-coding information. Introns expand proteomic diversity by allowing a single gene to encode multiple mRNA isoforms and thus multiple protein isoforms with distinct activities in specific tissues. Splicing is performed by the spliceosome – a dynamic assembly of RNA and proteins. During his postdoc, Sebastian used electron cryo-microscopy to solve some of the first high-resolution structures of the spliceosome. His Oxford group now studies how the activity and dynamics of the spliceosome are regulated to ensure correct splicing of different pre-mRNAs in specific tissues and developmental states.

Selected publications: