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Professor Constantin CoussiosBack to People

constantin-cossious
Subjects: Engineering Science
Department: Department of Engineering Science
College appointment: Professorial Fellow
Phone: 01865 617727

Background

Constantin Coussios was appointed to the first statutory professorship in Biomedical Engineering in January 2011, in the general area of drug delivery. He heads the Biomedical Ultrasonics and Biotherapy Laboratory (BUBBL) in the Oxford Institute of Biomedical Engineering (IBME). He holds a B.A., M.Eng., M.A. and Ph.D. from the University of Cambridge.

He worked as a post-doctoral researcher at the University of Cincinnati (Ohio, USA, 2001-02) and Boston University (Mass, USA, 2002-03) – the later as 2002-2003 F.V. Hunt Post-Doctoral Fellowship in Acoustics by the Acoustical Society of America. He then took up his post at Magdalen. Prof. Coussios serves on the Acoustical Society’s Technical Committee on Biomedical Ultrasound and served as a board member and Secretary of the International Society in Therapeutic Ultrasound between 2006 and 2010.

In 2007, he was awarded the Institute of Acoustics Young Investigator Award for Innovation in Acoustical Engineering, and was selected as one of seven nationwide recipients of an EPSRC Challenging Engineering Award. In 2009, he was elected a Fellow of the Acoustical Society of America, and received the Society’s R. Bruce Lindsay award in 2011. In 2012, he was awarded the Fred Lizzi award by the International Society for Therapeutic Ultrasound.

Research Interests

Biomedical applications of acoustics, fluid mechanics and control; Therapeutic ultrasound, for example the use of High-Intensity Focussed Ultrasound (HIFU) for non-invasive cancer therapy, and the use of ultrasound for targeted drug and gene delivery; transdermal drug delivery and methods of monitoring drug particle distribution and dissolution; Normothermic isolated organ perfusion for targeted drug and gene delivery, as well as organ preservation and repair prior to transplantation.

Selected Publications

*M. Bazan-Perergrino, B. Rifai, R. Carlisle, J. Choi, C. Arvanitis, L. Seymour and C-C. Coussios, ‘Cavitation-Enhanced Delivery of a Conditionally Replicating Oncolytic Adenovirus by Therapeutic Ultrasound’, J. Controlled Release 169: 40–47 (2013).

*C. Jensen, R. Ritchie, M. Gyongy, J.R.T. Collin, T. Leslie and C.-C. Coussios, “Spatio-Temporal Monitoring of HIFU Therapy by Passive Acoustic Mapping”, Radiology 262(1): 252-261 (2012).

*M. Gyongy and C.-C. Coussios, ‘Passive Spatial Mapping of Inertial Cavitation during HIFU Exposure”, IEEE Trans. Biomed. Eng. 57(1):48-56 (2010).

*J. Brockmann, S. Reddy, C.-C. Coussios, D. Piggott, D. Guirriero, D. Hughes, R. Morovat, D. Roy, L. Winter and P.J. Friend, ‘Normothermic Perfusion: a New Paradigm in Organ Preservation’, Annals of Surgery 250:1-6 (2009).

*C.-C. Coussios and R.A. Roy, ‘Applications of Acoustics and Cavitation to Non-Invasive Therapy and Drug Delivery’, Annual Review of Fluid Mechanics 40: 395-420 (2008).