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Professor Chris GarlandBack to People

chris-garland
Subjects: Biochemistry, Biomedical Sciences, Medicine
Department: Pharmacology
College appointment: Tutorial Fellow
Officer: Senior Dean of Arts

Background

I am a Tutorial Fellow and currently the Senior Dean of Arts at Magdalen. In the university, I am Professor of Vascular Pharmacology and run a research group in the Department of Pharmacology on Mansfield Road. Previously, I was Head of Pharmacology and held the established chair in Pharmacology at the University of Bath (2000-2008). Before that, I was Reader then Professor of Cardiovascular Pharmacology, University of Bristol and a Lecturer then Senior Lecturer in Pharmacology at the University of Southampton. I am also currently a Visiting Professor at the University of Queensland, Australia (2013-18). Previously, I held Visiting Professorships in the University of Bath (2008-12), University of Nagoya, Japan (2011), Monash University, Australia (2000-2003) and the National Academy of Sciences, Taiwan (2003).

Outside of universities, until recently I was Vice-President of the British Pharmacological Society and a council member of the Royal Society of Biology. I have also served on grant panels for the Wellcome Trust, British Heart Foundation and the Medical Research Council. In 2009, I was awarded the JR Vane Medal by the British Pharmacological Society, recognizing my research achievements in pharmacology.

Undergraduate Teaching

At Magdalen, I teach Physiology and Pharmacology to medical and biomedical science students.

Research Interests

My research investigates the cellular mechanisms that operate to enable the smallest arteries in our body to control blood pressure and flow. The research is of direct relevance to understanding how these minute arteries are affected by disease that leads to stroke and myocardial ischaemia/infarction (heart attack).

Selected Recent Publications

  • Garland CJ, Bagher P, Powell C, Ye X, Lemmey HAL, Borysova L, Dora KA. Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles. Science Signaling. (2017) 10 (486). pii: eaal3806. doi:10.1126/scisignal.aal3806.
  • Garland CJ, Smirnov SV, Bagher P, Lim CS, Huang CY,  Mitchell R, Stanley C,  Pinkney A, Dora KA. TRPM4 inhibitor 9-phenanthrol activates endothelial cell intermediate conductance calcium activated potassium channels in rat isolated mesenteric artery. (2015). Br. J. Pharmacol., 172, 1114-23.
  • Bagher P, Garland CJ, Scaffolding Builds to Reduce Blood Pressure. (2014). Science Signaling, 7 (333) pe 16.
  • Bagher P, Beleznai T, Kansui Y, Mitchell R, Garland CJ, Dora KA. Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc Natl Acad Sci U S A. (2012). 109: 18174-18179.
  • Garland CJ, Hiley CR, Dora KA. EDHF: spreading the influence of the endothelium. (2011). Br J Pharmacol. 164: 839-852.